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Clinical trials for Drug Interaction

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   43881   clinical trials with a EudraCT protocol, of which   7295   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    260 result(s) found for: Drug Interaction. Displaying page 1 of 13.
    1  2  3  4  5  6  7  8  9  Next» Last»»
    EudraCT Number: 2012-000363-24 Sponsor Protocol Number: Met-Dipy001 Start Date*: 2012-04-18
    Sponsor Name:Radboud University Medical Centre Nijmegen
    Full Title: The effect of dipyridamole on the pharmacokinetics of metformin.
    Medical condition: The antihyperglycemic drug metformin and the thrombocyte aggregation inhibitor dipyridamole are often used concomitantly in patients with diabetes who have suffered a transient ischemic attack or s...
    Disease: Version SOC Term Classification Code Term Level
    14.1 10018065 - General disorders and administration site conditions 10068071 Inhibitory drug interaction PT
    14.1 10018065 - General disorders and administration site conditions 10013710 Drug interaction PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2007-006135-32 Sponsor Protocol Number: JohnOxy 1.0 2007 Start Date*: 2008-01-16
    Sponsor Name:Klaus Tapio Olkkola
    Full Title: Effect of St. John`s wort on the pharmacokinetics and pharmacodynamics of oral oxycodone: A two-phase double-blind cross-over study in healthy volunteers /Mäkikuisman vaikutus suun kautta annetun o...
    Medical condition: Drug interaction study
    Disease:
    Population Age: Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2022-003275-42 Sponsor Protocol Number: MEC-2021-0478 Start Date*: 2023-04-13
    Sponsor Name:
    Full Title: The influence of different DIets on ALECTinib pharmacokinetics in NSCLC patients; the DIALECT study.
    Medical condition: Weight gain is a common side effect of alectinib therapy. Semaglutide could be used as medical anti-obesity drug to prevent alectinib-induced weight gain. Since semaglutide delays gastric emptying,...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2020-001070-29 Sponsor Protocol Number: CRF005 Start Date*: 2023-05-26
    Sponsor Name:Chelsea and Westminster NHS Foundation Trust
    Full Title: Efficacy, tolerability and acceptability of the single tablet regimen (STR) Biktarvy® by trans people living with HIV (TPLWH)
    Medical condition: Human Immunodeficiency Virus (HIV) infection
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004862 10020441 Human immunodeficiency virus infection, unspecified LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2010-018233-21 Sponsor Protocol Number: WEC 0910 Start Date*: 2010-03-31
    Sponsor Name:Leiden University Medical Centre
    Full Title: Modeling the respiratory effects of subanesthetic doses of propofol under closed-loop or non-steady-state conditions without and with a remifentanil background infusion in healthy volunteers.
    Medical condition: This study is performed in healthy volunteers. The study is aimed at investigating the effect of propofol and remifentanil-propofol interaction on breathing in awake, non-artificially ventilated vo...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2019-000276-41 Sponsor Protocol Number: SUMO Start Date*: 2020-03-05
    Sponsor Name:Erasmus MC
    Full Title: Study on the effects of an OCT2/MATE1 substrate (metformin) and inhibitor (cimetidine) on the exposure of trifluridine/tipiracil (Lonsurf®) in patients with metastatic colorectal cancer (mCRC).
    Medical condition: patients with mCRC with an indication for lonsurf treatment.
    Disease:
    Population Age: Gender:
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-016998-15 Sponsor Protocol Number: TeriTrama_1.0 Start Date*: 2009-12-03
    Sponsor Name:University of Turku
    Full Title: Effect of terbinafine and itraconazole on the pharmacokinetics and pharmacodynamics of oral tramadol: A three-phase randomized balanced cross-over study in healthy volunteers
    Medical condition: Acute postoperative pain and chronic pain syndromes
    Disease: Version SOC Term Classification Code Term Level
    12.1 10066714 Acute pain LLT
    12.1 10049475 Chronic pain LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: View results
    EudraCT Number: 2010-020617-82 Sponsor Protocol Number: TicloTrama_1.0 Start Date*: 2010-08-12
    Sponsor Name:University of Turku
    Full Title: Effect of itraconazole and ticlopidine on the pharmacokinetics and pharmacodynamics of oral tramadol: A three-phase randomized balanced cross-over study in healthy volunteers
    Medical condition: Acute postoperative pain and chronic pain syndromes
    Disease: Version SOC Term Classification Code Term Level
    12.1 10066714 Acute pain LLT
    12.1 10049475 Chronic pain LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: View results
    EudraCT Number: 2020-005224-12 Sponsor Protocol Number: KAFTAC2020 Start Date*: 2021-05-01
    Sponsor Name:Haga Teaching Hospital
    Full Title: Elexacaftor/tezacaftor/ivacaftor in patients with cystic fibrosis using tacrolimus, a drug - drug interaction study
    Medical condition: cystic fibrosis patients
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2017-000945-37 Sponsor Protocol Number: PIRAD-001 Start Date*: 2017-05-01
    Sponsor Name:UMCG
    Full Title: Pharmacodynamic interactions between remifentanil and dexmedetomidine (PIRAD)
    Medical condition: We will include 30 healthy volunteers (American Society of Anesthesiologists 1) stratified to age groups to different sequence of anesthesia regimen
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2007-003347-73 Sponsor Protocol Number: UMCN-AKF 07.02 Start Date*: 2007-12-04
    Sponsor Name:Radboud University Nijmegen Medical Centre
    Full Title: A pharmacokinetic evaluation of the addition of Aprepitant to the Cisplatin - Etoposide (CE) treatment of patients with metastatic lung carcinoma (ACE).
    Medical condition: Nausea and vomiting after using moderate emetogenic cytostatics such as etoposide and cisplatin for the treatment of patients with metastatic lung carcinoma.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10056989 Nausea post chemotherapy LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2014-004921-41 Sponsor Protocol Number: P06332 Start Date*: 2015-02-24
    Sponsor Name:Corporation Schering-Plough K.K.
    Full Title: Multicenter, double-blind, randomized, placebo-controlled study of mometasone furoate nasal spray in pediatric subjects with perennial allergic rhinitis
    Medical condition: perennial allergic rhinitis
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2019-004240-30 Sponsor Protocol Number: PS-ISA-01 Start Date*: 2020-01-24
    Sponsor Name:FUNDACIÓN PARA LA INVESTIGACION BIOMEDICA HU PUERTA DE HIERRO MAJADAHONDA
    Full Title: Phase IV, unicentric, multiple dose, clinical trial, with a single treatment arm to evaluate bronchopulmonary penetration of isavuconazole in pulmonary transplant recipients (PBISA01)
    Medical condition: Lung transplant recipients with a diagnosis of invasive fungal disease
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-003259-20 Sponsor Protocol Number: VenlaTrama_1.0 Start Date*: 2011-09-08
    Sponsor Name:University of Turku
    Full Title: Effect of duloxetine and venlafaxine on the pharmacokinetics and pharmacodynamics of oral tramadol: A three-phase randomized balanced cross-over study in healthy volunteers
    Medical condition: Acute postoperative pain and chronic pain syndromes
    Disease: Version SOC Term Classification Code Term Level
    14.0 10018065 - General disorders and administration site conditions 10066714 Acute pain LLT
    14.0 10018065 - General disorders and administration site conditions 10049475 Chronic pain LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2004-005071-42 Sponsor Protocol Number: CERL080AGB03 Start Date*: 2005-05-06
    Sponsor Name:Novartis Pharmaceuticals UK Limited
    Full Title: A study of the effect of conversion to Myfortic on quality of life in patients with gastrointestinal (GI) symptoms related to MMF therapy after renal transplantation (MYQOL).
    Medical condition: Renal transplantation
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IE (Completed) GB (Completed)
    Trial results: View results
    EudraCT Number: 2020-002621-29 Sponsor Protocol Number: tacpat Start Date*: 2021-06-08
    Sponsor Name:oslo university hospital
    Full Title: Effect of patiromer on pharmacokinetics of immunosuppressive drugs in renal transplant recipients
    Medical condition: hyperkalemia transplantation immunosuppression
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-006416-30 Sponsor Protocol Number: INPAWA 2 Start Date*: 2006-12-28
    Sponsor Name:Unité de Recherches Thérapeutiques
    Full Title: Effect of two distinct dosing regimen of acetaminophen on the anticoagulant effect of warfarin
    Medical condition: Arterial and venous thromboembolic disease including atrial fibrillation
    Disease: Version SOC Term Classification Code Term Level
    8.1 10043565 Thromboembolic event LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-002237-22 Sponsor Protocol Number: MK-0518B-196 Start Date*: 2015-05-22
    Sponsor Name:Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc.
    Full Title: A Study to Compare the Pharmacokinetics of a Fixed-Dose Combination of Raltegravir and Lamivudine to Co-administered Raltegravir and Lamivudine
    Medical condition: HIV-1 Infection
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2011-001684-50 Sponsor Protocol Number: 11015 Start Date*: 2011-06-20
    Sponsor Name:University of Nottingham
    Full Title: 'Stem cell Trial of recovery EnhanceMent after Stroke 3’ (STEMS 3)- a pilot randomised controlled trial of G-CSF and therapy in chronic stroke
    Medical condition: Stroke with residual deficit
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2008-007647-14 Sponsor Protocol Number: Nabu1A2 Start Date*: 2009-01-07
    Sponsor Name:Turku University Hospital
    Full Title: The effect of fluvoxamine and ciprofloxacin on the pharmacokinetics and pharmacodynamics of nabumetone: A three-phase double-blind placebo-controlled cross-over study.
    Medical condition: Pharmacokinetics and pharmacodynamics, healthy volunteer trial
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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